Expression Pattern and Value of Brain-Derived Neurotrophic Factor in Periodontitis.

ABSTRACT:

Background

Periodontitis is a common human disease with an increasing incidence. Brain-derived neurotrophic factor (BDNF) is known to play a crucial role in the regeneration of periodontal tissue; however, the expression, methylation level, molecular function, and clinical value of BDNF in periodontitis require further investigation. This study aimed to investigate the expression and potential functions of BDNF in periodontitis.

Methods

RNA expression and methylation data were obtained from the Gene Expression Omnibus (GEO) database, and the expression and methylation levels of BDNF were compared between periodontitis and normal tissues. In addition, bioinformatics analysis was performed to investigate the downstream molecular functions of BDNF. Finally, Reverse transcriptio

SUBMITTER: Chen H 

PROVIDER: S-EPMC10390664 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature