Gut microbiota in children with split-dose bowel preparations revealed by metagenomics.

ABSTRACT:

Objective

Split-dose polyethylene glycol (PEG) is routinely used for bowel preparation before colonoscopy. This study aimed to investigate the composition of gut microbiota and its functions in pediatric patients undergoing split-dose PEG bowel preparation for colonoscopy to understand the stability and resilience of gut microbiota.

Material and methods

From September to December 2021, 19 pediatric patients were enrolled at Shenzhen Children's Hospital and 76 samples (4 time points) were analyzed using metagenomics. Time points included Time_1 (one day before bowel preparation), Time_2 (one day after colonoscopy), Time_3 (two weeks after bowel preparation), and Time_4 (four weeks after bowel preparation).

Result

Alpha diversity comparison at both the species and gene

SUBMITTER: Zou Y 

PROVIDER: S-EPMC10390731 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature