Multivalent vaccines demonstrate immunogenicity and protect against Coxiella burnetii aerosol challenge.

ABSTRACT: Vaccines are among the most cost-effective public health measures for controlling infectious diseases. Coxiella burnetii is the etiological agent of Q fever, a disease with a wide clinical spectrum that ranges from mild symptoms, such as fever and fatigue, to more severe disease, such as pneumonia and endocarditis. The formalin-inactivated whole-cell vaccine Q-VAX^® contains hundreds of antigens and confers lifelong protection in humans, but prior sensitization from infection or vaccination can result in deleterious reactogenic responses to vaccination. Consequently, there is great interest in developing non-reactogenic alternatives based on adjuvanted recombinant proteins. In this study, we aimed to develop a multivalent vaccine that conferred protection with reduced reac

SUBMITTER: Jan S 

PROVIDER: S-EPMC10390735 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature