Transcriptomic profiles of multiple organ dysfunction syndrome phenotypes in pediatric critical influenza.

ABSTRACT:

Background

Influenza virus is responsible for a large global burden of disease, especially in children. Multiple Organ Dysfunction Syndrome (MODS) is a life-threatening and fatal complication of severe influenza infection.

Methods

We measured RNA expression of 469 biologically plausible candidate genes in children admitted to North American pediatric intensive care units with severe influenza virus infection with and without MODS. Whole blood samples from 191 influenza-infected children (median age 6.4 years, IQR: 2.2, 11) were collected a median of 27 hours following admission; for 45 children a second blood sample was collected approximately seven days later. Extracted RNA was hybridized to NanoString mRNA probes, counts normalized, and analyzed using linear models control

SUBMITTER: Novak T 

PROVIDER: S-EPMC10390830 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature