Effects of Using Different Indirect Techniques on the Calculation of Reference Intervals: Observational Study.

ABSTRACT:

Background

Reference intervals (RIs) play an important role in clinical decision-making. However, due to the time, labor, and financial costs involved in establishing RIs using direct means, the use of indirect methods, based on big data previously obtained from clinical laboratories, is getting increasing attention. Different indirect techniques combined with different data transformation methods and outlier removal might cause differences in the calculation of RIs. However, there are few systematic evaluations of this.

Objective

This study used data derived from direct methods as reference standards and evaluated the accuracy of combinations of different data transformation, outlier removal, and indirect techniques in establishing complete blood count (CBC) RIs for large-s

SUBMITTER: Yang D 

PROVIDER: S-EPMC10390978 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature