Calcitonin Gene-Related Peptide Monoclonal Antibodies and Risk of SARS-CoV-2 Infection and Severe COVID-19 Outcomes Among Veterans With Migraine Disorder.

ABSTRACT:

Importance

Calcitonin gene-related peptide (CGRP), a neuropeptide involved in migraine pathophysiology, is also a key neuroimmune modulator. CGRP antagonists may help mitigate the hyperinflammatory response observed in patients with COVID-19; however, findings from the literature are contradictory, and to date, no study has investigated the safety and effectiveness of CGRP antagonists against COVID-19.

Objective

To evaluate the association between CGRP monoclonal antibody (mAb) treatment and risk of SARS-CoV-2 infection and sequela hospitalization, requiring supplemental oxygen, use of mechanical ventilation, or death.

Design, setting, and participants

This retrospective cohort study analyzed the electronic health records of US veterans aged 18 to 65 years who were di

SUBMITTER: Wang K 

PROVIDER: S-EPMC10391301 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature