EpiMix is an integrative tool for epigenomic subtyping using DNA methylation.

ABSTRACT: DNA methylation (DNAme) is a major epigenetic factor influencing gene expression with alterations leading to cancer and immunological and cardiovascular diseases. Recent technological advances have enabled genome-wide profiling of DNAme in large human cohorts. There is a need for analytical methods that can more sensitively detect differential methylation profiles present in subsets of individuals from these heterogeneous, population-level datasets. We developed an end-to-end analytical framework named "EpiMix" for population-level analysis of DNAme and gene expression. Compared with existing methods, EpiMix showed higher sensitivity in detecting abnormal DNAme that was present in only small patient subsets. We extended the model-based analyses of EpiMix to cis-regulatory elements w

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC10391348 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature