Distinct gene expression profiles underlie morphological and etiological differences in pediatric cataracts.

ABSTRACT:

Purpose

Pediatric cataract is a major cause of preventable childhood blindness worldwide. Although genetic mutations or infections have been described in patients, the mechanistic basis of human cataract development remains poorly understood. Therefore, gene expression of structural, developmental, profibrotic, and transcription factors in phenotypically and etiologically distinct forms of pediatric cataracts were evaluated.

Methods

This cross-sectional study included 89 pediatric cataract subjects subtyped into 1) prenatal infectious (cytomegalovirus, rubella, and combined cytomegalovirus with rubella infection), 2) prenatal non-infectious, 3) posterior capsular anomalies, 4) postnatal, 5) traumatic, and 6) secondary, and compared to clear, non-cataractous material of eyes

SUBMITTER: Shanbagh S 

PROVIDER: S-EPMC10391435 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature