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Base-editing screens illuminate variant effects in human hematopoiesis.

ABSTRACT: In a recent issue of Cell, Martin-Rufino et al. develop a strategy for performing high-throughput base-editing CRISPR screens coupled with single-cell readouts in the context of human hematopoiesis. Through a series of proof-of-principle experiments, the authors demonstrate the potential of base-editing screens for the study and treatment of hematological disorders.

SUBMITTER: Vaitsiankova A

PROVIDER: S-EPMC10391558 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Base-editing screens illuminate variant effects in human hematopoiesis.

Vaitsiankova Alina A Thakar Tanay T Ciccia Alberto A

Cell reports methods 20230724 7

In a recent issue of <i>Cell</i>, Martin-Rufino et al. develop a strategy for performing high-throughput base-editing CRISPR screens coupled with single-cell readouts in the context of human hematopoiesis. Through a series of proof-of-principle experiments, the authors demonstrate the potential of base-editing screens for the study and treatment of hematological disorders. ...[more]

PMID: 37533644

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