A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.

ABSTRACT: Automated home-cage monitoring systems present a valuable tool for comprehensive phenotyping of natural behaviors. However, current systems often involve complex training routines, water or food restriction, and probe a limited range of behaviors. Here, we present a fully automated home-cage monitoring system for cognitive and behavioral phenotyping in mice. The system incorporates T-maze alternation, novel object recognition, and object-in-place recognition tests combined with monitoring of locomotion, drinking, and quiescence patterns, all carried out over long periods. Mice learn the tasks rapidly without any need for water or food restrictions. Behavioral characterization employs a deep convolutional neural network image analysis. We show that combined statistical properties of multipl

SUBMITTER: Ho H 

PROVIDER: S-EPMC10391580 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature