Central sensitization in CRPS patients with widespread pain: a cross-sectional study.

ABSTRACT:

Objective

Widespread pain hypersensitivity and enhanced temporal summation of pain (TSP) are commonly reported in patients with complex regional pain syndrome (CRPS) and discussed as proxies for central sensitization. This study aimed to directly relate such signs of neuronal hyperexcitability to the pain phenotype of CRPS patients.

Methods

Twenty-one CRPS patients and 20 healthy controls (HC) were recruited. The pain phenotype including spatial pain extent (assessed in % body surface) and intensity were assessed and related to widespread pain hypersensitivity, TSP, and psychological factors. Quantitative sensory testing (QST) was performed in the affected, the contralateral and a remote (control) area.

Results

CRPS patients showed decreased pressure pain thresholds i

SUBMITTER: De Schoenmacker I 

PROVIDER: S-EPMC10391588 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature