Bioinspired Synthesis of Platensimycin from Natural ent-Kaurenoic Acids.

ABSTRACT: The biomimetic formal synthesis of the antibiotic platensimycin for the treatment of infection by multidrug-resistant bacteria was accomplished starting from either ent-kaurenoic acid or grandiflorenic acid, each of which is a natural compound available in multigram scale from its natural source. Apart from the natural origin of the selected precursors, the keys of the described approach are the long-distance functionalization of ent-kaurenoic acid at C11 and the efficient protocol for the A-ring degradation of the diterpene framework.

SUBMITTER: Perez A 

PROVIDER: S-EPMC10391625 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature