Dose-response relationship between multiple trace elements and risk of all-cause mortality: a prospective cohort study.

ABSTRACT:

Objectives

We aimed to prospectively investigate the independent and combined relationship between trace elements concentrations [blood (selenium, manganese), serum (copper, zinc), and urine (cobalt, molybdenum, tin, strontium, iodine)] and all-cause mortality.

Methods

This study included 5,412 individuals with demographical, examination, and laboratory data from the National Health and Nutrition Examination Survey. Three statistical models, including Cox proportional hazards models, restricted cubic spline models, and Bayesian kernel machine regression (BKMR) models, were conducted to estimate the longitudinal relationship between trace elements and all-cause mortality.

Results

There were 356 deaths documented with a median follow-up time of 70 months. In the single-

SUBMITTER: Zhao S 

PROVIDER: S-EPMC10391637 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature