Integrative genomic testing of cancer survival using semiparametric linear transformation models.

ABSTRACT: The wide availability of multi-dimensional genomic data has spurred increasing interests in integrating multi-platform genomic data. Integrative analysis of cancer genome landscape can potentially lead to deeper understanding of the biological process of cancer. We integrate epigenetics (DNA methylation and microRNA expression) and gene expression data in tumor genome to delineate the association between different aspects of the biological processes and brain tumor survival. To model the association, we employ a flexible semiparametric linear transformation model that incorporates both the main effects of these genomic measures as well as the possible interactions among them. We develop variance component tests to examine different coordinated effects by testing various subsets of model co

SUBMITTER: Huang YT 

PROVIDER: S-EPMC10392002 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature