BASP1 expression is associated with poor prognosis and is correlated with immune infiltration in gastric cancer.

ABSTRACT: BASP1 is a membrane-bound protein that plays a promotional or inhibitory role in a variety of tumors; however, its role in gastric cancer (GC) and in the immune microenvironment has not been reported. The objectives of this study were to determine whether BASP1 is a valuable prognostic marker for GC and to explore its role in the immune microenvironment of GC. The expression level of BASP1 in GC was analyzed based on the TCGA dataset and further verified using GSE54129 and GSE161533 datasets, immunohistochemistry, and western blotting. The association between BASP1 and clinicopathological characteristics, as well as its predictive value, were examined using the STAD dataset. Cox regression analysis was performed to determine whether BASP1 can be used as an independent prognostic indicator

SUBMITTER: Wang T 

PROVIDER: S-EPMC10392055 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature