Effects of theta phase precessing optogenetic intervention on hippocampal neuronal reactivation and spatial maps.

ABSTRACT: As animals explore environments, hippocampal place cells sequentially fire at progressively earlier phases of theta oscillations in hippocampal local field potentials. In this study, we evaluated the network-level significance of theta phase-entrained neuronal activity in organizing place cell spike patterns. A closed-loop system was developed in which optogenetic stimulation with a temporal pattern replicating theta phase precession is delivered to hippocampal CA1 neurons when rats traversed a particular region on a linear track. Place cells that had place fields during phase precessing stimulation, but not random phase stimulation, showed stronger reactivation during hippocampal sharp-wave ripples in a subsequent rest period. After the rest period, place cells with place fields that emer

SUBMITTER: Aoki Y 

PROVIDER: S-EPMC10392074 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature