Multi-omic approach to decipher the impact of skincare products with pre/postbiotics on skin microbiome and metabolome.

ABSTRACT:

Introduction

Although pre/pro/postbiotics have become more prevalent in dermatologic and cosmetic fields, the mode of action when topically applied is largely unknown. A multi-omic approach was applied to decipher the impact of the skincare products with pre/postbiotics on skin microbiome and metabolome.

Methods

Subjects with dry skin applied a body wash and body lotion with or without pre/postbiotics for 6 weeks. Skin hydration was measured at baseline, 3 and 6 weeks. Skin swabs were collected for 16S rRNA gene sequencing, metagenomics and metabolomics analysis.

Results

Skin hydration significantly increased in both groups. The prebiotic group significantly reduced opportunistic pathogens, e.g., Pseudomonas stutzeri and Sphingomonas anadarae, and increa

SUBMITTER: Li M 

PROVIDER: S-EPMC10392128 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature