Integrative structural modelling and visualisation of a cellular organelle.
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ABSTRACT:
SUBMITTER: Autin L
PROVIDER: S-EPMC10392685 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
Integrative structural modelling and visualisation of a cellular organelle.
Autin Ludovic L Barbaro Brett A BA Jewett Andrew I AI Ekman Axel A Verma Shruti S Olson Arthur J AJ Goodsell David S DS
QRB discovery 20220809
Models of insulin secretory vesicles from pancreatic beta cells have been created using the cellPACK suite of tools to research, curate, construct and visualise the current state of knowledge. The model integrates experimental information from proteomics, structural biology, cryoelectron microscopy and X-ray tomography, and is used to generate models of mature and immature vesicles. A new method was developed to generate a confidence score that reconciles inconsistencies between three available ...[more]
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