Using mixed reality technique combines multimodal imaging signatures to adjuvant glioma photodynamic therapy.

ABSTRACT:

Background

Photodynamic therapy (PDT) promotes significant tumor regression and extends the lifetime of patients. The actual operation of PDT often relies on the subjective judgment of experienced neurosurgeons. Patients can benefit more from precisely targeting PDT's key operating zones.

Methods

We used magnetic resonance imaging scans and created 3D digital models of patient anatomy. Multiple images are aligned and merged in STL format. Neurosurgeons use HoloLens to import reconstructions and assist in PDT execution. Also, immunohistochemistry was used to explore the association of hyperperfusion sites in PDT of glioma with patient survival.

Results

We constructed satisfactory 3D visualization of glioma models and accurately localized the hyperperfused areas of the

SUBMITTER: Dong J 

PROVIDER: S-EPMC10392826 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature