Cortical cerebrovascular and metabolic perturbations in the 5xFAD mouse model of Alzheimer's disease.

ABSTRACT:

Introduction

The 5xFAD mouse is a popular model of familial Alzheimer's disease (AD) that is characterized by early beta-amyloid (Aβ) deposition and cognitive decrements. Despite numerous studies, the 5xFAD mouse has not been comprehensively phenotyped for vascular and metabolic perturbations over its lifespan.

Methods

Male and female 5xFAD and wild type (WT) littermates underwent in vivo ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging at 4, 6, and 12 months of age to assess regional glucose metabolism. A separate cohort of mice (4, 8, 12 months) underwent "vessel painting" which labels all cerebral vessels and were analyzed for vascular characteristics such as vessel density, junction density, vessel length, network complexity, numb

SUBMITTER: Jullienne A 

PROVIDER: S-EPMC10392850 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature