Serum Proteomic Profiling in Patients with Chronic Obstructive Pulmonary Disease.

ABSTRACT:

Purpose

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with high morbidity and mortality rates. This study used proteomic profiling of serum to identify the differentially expressed proteins in COPD patients compared with healthy controls, to expand the knowledge of COPD pathogenesis and to ascertain potential new targets for diagnosis and treatment of COPD.

Methods

Serum samples were collected from 56 participants (COPD group n = 28; Healthy Control group n = 28). A data-independent acquisition quantitative proteomics approach was used to identify differentially expressed proteins (DEPs) between the two groups. Gene Ontology (GO) functional annotation, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway functional enrichment, and protein-protein

SUBMITTER: Wu S 

PROVIDER: S-EPMC10392904 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature