Association of torque teno virus viremia with liver fibrosis in the first year after liver transplantation.

ABSTRACT:

Introduction

Torque teno virus (TTV) replication is controlled by immune status, mirroring a degree of immunosuppression after solid organ transplantation. TTV viraemia (TTVv) was associated with acute cellular rejection and infection within the first year after liver transplantation (LT). Long-term data on TTV after LT and correlation with graft injury from protocol biopsies are limited.

Methods

One hundred plasma samples paired with graft biopsies from a prospective single-center biorepository were analyzed.

Results

The median time post-LT was 23 months (range, 2-298). TTVv was detectable in 97%. TTVv decreased over time after LT and showed a significant decline from year 1 to later time points. Hence, TTVv correlated negatively with histologic liver fibrosis (liver

SUBMITTER: Engel B 

PROVIDER: S-EPMC10392936 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature