Histone variants shape chromatin states in Arabidopsis.

ABSTRACT: How different intrinsic sequence variations and regulatory modifications of histones combine in nucleosomes remain unclear. To test the importance of histone variants in the organization of chromatin we investigated how histone variants and histone modifications assemble in the Arabidopsis thaliana genome. We showed that a limited number of chromatin states divide euchromatin and heterochromatin into several subdomains. We found that histone variants are as significant as histone modifications in determining the composition of chromatin states. Particularly strong associations were observed between H2A variants and specific combinations of histone modifications. To study the role of H2A variants in organizing chromatin states we determined the role of the chromatin remodeler DECREAS

SUBMITTER: Jamge B 

PROVIDER: S-EPMC10393023 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature