Subclinical atherosclerosis and accelerated epigenetic age mediated by inflammation: a multi-omics study.

ABSTRACT:

Aims

Epigenetic age is emerging as a personalized and accurate predictor of biological age. The aim of this article is to assess the association of subclinical atherosclerosis with accelerated epigenetic age and to investigate the underlying mechanisms mediating this association.

Methods and results

Whole blood methylomics, transcriptomics, and plasma proteomics were obtained for 391 participants of the Progression of Early Subclinical Atherosclerosis study. Epigenetic age was calculated from methylomics data for each participant. Its divergence from chronological age is termed epigenetic age acceleration. Subclinical atherosclerosis burden was estimated by multi-territory 2D/3D vascular ultrasound and by coronary artery calcification. In healthy individuals, the presence, e

SUBMITTER: Sanchez-Cabo F 

PROVIDER: S-EPMC10393076 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature