Sirtuin 2 deficiency aggravates ageing-induced vascular remodelling in humans and mice.

ABSTRACT:

Aims

The mechanisms underlying ageing-induced vascular remodelling remain unclear. This study investigates the role and underlying mechanisms of the cytoplasmic deacetylase sirtuin 2 (SIRT2) in ageing-induced vascular remodelling.

Methods and results

Transcriptome and quantitative real-time PCR data were used to analyse sirtuin expression. Young and old wild-type and Sirt2 knockout mice were used to explore vascular function and pathological remodelling. RNA-seq, histochemical staining, and biochemical assays were used to evaluate the effects of Sirt2 knockout on the vascular transcriptome and pathological remodelling and explore the underlying biochemical mechanisms. Among the sirtuins, SIRT2 had the highest levels in human and mouse aortas. Sirtuin 2 activity was reduced i

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10393077 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature