Time-dependent effects of endogenous hyperglucagonemia on glucose homeostasis and hepatic glucagon action.

ABSTRACT: Elevation of glucagon levels and increase in α cell proliferation is associated with states of hyperglycemia in diabetes. A better understanding of the molecular mechanisms governing glucagon secretion could have major implications for understanding abnormal responses to hypoglycemia in patients with diabetes and provide novel avenues for diabetes management. Using mice with inducible induction of Rheb1 in α cells (αRhebTg mice), we showed that short-term activation of mTORC1 signaling is sufficient to induce hyperglucagonemia through increased glucagon secretion. Hyperglucagonemia in αRhebTg mice was also associated with an increase in α cell size and mass expansion. This model allowed us to identify the effects of chronic and short-term hyperglucagonemia on glucose homeostasis by regulat

SUBMITTER: Lubaczeuski C 

PROVIDER: S-EPMC10393226 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature