LASSI-L detects early cognitive changes in pre-motor manifest Huntington's disease: a replication and validation study.

ABSTRACT:

Background and objectives

Cognitive decline is an important early sign in pre-motor manifest Huntington's disease (preHD) and is characterized by deficits across multiple domains including executive function, psychomotor processing speed, and memory retrieval. Prior work suggested that the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L)-a verbal learning task that simultaneously targets these domains - could capture early cognitive changes in preHD. The current study aimed to replicate, validate and further analyze the LASSI-L in preHD using larger datasets.

Methods

LASSI-L was administered to 50 participants (25 preHD and 25 Healthy Controls) matched for age, education, and sex in a longitudinal study of disease progression and compared to perform

SUBMITTER: Sierra LA 

PROVIDER: S-EPMC10393264 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature