Can BioSAXS detect ultrastructural changes of antifungal compounds in Candida albicans?-an exploratory study.

ABSTRACT: The opportunistic yeast Candida albicans is the most common cause of candidiasis. With only four classes of antifungal drugs on the market, resistance is becoming a problem in the treatment of fungal infections, especially in immunocompromised patients. The development of novel antifungal drugs with different modes of action is urgent. In 2016, we developed a groundbreaking new medium-throughput method to distinguish the effects of antibacterial agents. Using small-angle X-ray scattering for biological samples (BioSAXS), it is now possible to screen hundreds of new antibacterial compounds and select those with the highest probability for a novel mode of action. However, yeast (eukaryotic) cells are highly structured compared to bacteria. The fundamental question to answer was if the

SUBMITTER: Hilpert K 

PROVIDER: S-EPMC10393279 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature