Clinical validation and diagnostic accuracy of ^99mTc-EDDA/HYNIC-TOC compared to ¹¹¹In-DTPA-octreotide in patients with neuroendocrine tumours: the LACOG 0214 study.

ABSTRACT: ^99mTc-EDDA/HYNIC-TOC is an easily available and cheaper radionuclide that could be used for somatostatin-receptor-based imaging of neuroendocrine tumours (NETs). We aimed to evaluate the diagnostic performance of ^99mTc-EDDA/HYNIC-TOC compared to¹¹¹In-DTPA-octreotide in patients (pts) with NETs. We performed a prospective diagnostic study including pts with biopsy-confirmed NET and at least one visible lesion at conventional imaging. Two independent nuclear medicine physicians evaluated pts who underwent ^99mTc and ¹¹¹In scans and images. The primary outcome was comparative diagnostic accuracy of ^99mTc and ¹¹¹In. Secondary outcomes include safety. Nine pts were included and performed 14 paired scans. Overall, 126 le

SUBMITTER: Moriguchi-Jeckel CM 

PROVIDER: S-EPMC10393301 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature