Blockage of STAT3 during epileptogenesis prevents GABAergic loss and imprinting of the epileptic state.

ABSTRACT: Epilepsy, characterized by recurrent unprovoked seizures resulting from a wide variety of causes, is one of the world's most prominent neurological disabilities. Seizures, which are an expression of neuronal network dysfunction, occur in a positive feedback loop of concomitant factors, including neuro-inflammatory responses, where seizures generate more seizures. Among other pathways involved in inflammatory responses, the JAK/STAT signalling pathway has been proposed to participate in epilepsy. Here, we tested an in vitro model of temporal lobe epilepsy, with the hypothesis that acute blockage of STAT3-phosphorylation during epileptogenesis would prevent structural damage in the hippocampal circuitry and the imprinting of both neural epileptic activity and inflammatory glial states. We pe

SUBMITTER: Martin-Suarez S 

PROVIDER: S-EPMC10393395 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature