Cholinergic system correlates of postural control changes in Parkinson's disease freezers.

ABSTRACT: Postural instability and freezing of gait are the most debilitating dopamine-refractory motor impairments in advanced stages of Parkinson's disease because of increased risk of falls and poorer quality of life. Recent findings suggest an inability to efficaciously utilize vestibular information during static posturography among people with Parkinson's disease who exhibit freezing of gait, with associated changes in cholinergic system integrity as assessed by vesicular acetylcholine transporter PET. There is a lack of adequate understanding of how postural control varies as a function of available sensory information in patients with Parkinson's disease with freezing of gait. The goal of this cross-sectional study was to examine cerebral cholinergic system changes that associate with inter-

SUBMITTER: Roytman S 

PROVIDER: S-EPMC10393403 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature