[Identification of key pathways and drug repurposing for anaplastic thyroid carcinoma by integrated bioinformatics analysis].

ABSTRACT:

Objective

To identify hub genes and key pathways associated with anaplastic thyroid carcinoma (ATC), and to explore possible intervention strategy.

Methods

The differentially expressed genes (DEGs) in ATC were identified by Gene Expression Omnibus (GEO) combined with using R language; the pathway enrichment of DEGs were performed by using Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO). The protein-protein interaction (PPI) network of DEGs was constructed by STRING database and visualized by Cytoscape. Furthermore, the hub genes and key nodes were calculated by MCODE. Finally, the drug repurposing was performed by L1000CDS².

Results

A total of 2087 DEGs were identified. The DEGs were clustered based on functions and pathways with signi

SUBMITTER: Pan Z 

PROVIDER: S-EPMC10393701 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature