Pathogenic selection promotes adaptive immune variations against serious bottlenecks in early invasions of bullfrogs.

ABSTRACT: Adaptive genetic variations are key for understanding evolutionary processes influencing invasions. However, we have limited knowledge on how adaptive genetic diversity in invasive species responds to new pathogenic environments. Here, we compared variations in immune major histocompatibility complex (MHC) class-II β gene and neutral loci in relation to pathogenic chytrid fungus (Batrachochytrium dendrobatidis, Bd) infection across invasive and native populations of American bullfrog between China and United States (US). Chinese invasive populations show a 60% reduction in neutral cytb variations relative to US native populations, and there were similar MHC variation and functional diversity between them. One MHC allele private to China was under recent positive selection and associ

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10393753 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature