Metabolic dysfunction-associated fatty liver disease and the risk of hepatocellular carcinoma.

ABSTRACT:

Background & aims

The metabolic dysfunction-associated fatty liver disease (MAFLD) is a new inclusive term proposed to replace non-alcoholic fatty liver disease (NAFLD). We analysed whether hepatocellular carcinoma (HCC) risk differs by MAFLD or NAFLD status in a large sample of asymptomatic adults.

Methods

A cohort comprising 73,691 adults were followed up for the development of HCC. NAFLD was diagnosed among participants without other liver diseases (n = 65,992).

Results

Participants with MAFLD showed higher incidence of HCC than those without MAFLD (0.37 and 0.24 per 1,000 person-years, respectively; p = 0.006). However, MAFLD was not an independent factor associated with HCC in multivariable adjusted analysis (hazard ratio [HR] 1.21; 95% CI 0.92-1.60). When

SUBMITTER: Song BG 

PROVIDER: S-EPMC10393797 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature