Engineering a versatile and retrievable cell macroencapsulation device for the delivery of therapeutic proteins.

ABSTRACT: Encapsulated cell therapy holds a great potential to deliver sustained levels of highly potent therapeutic proteins to patients and improve chronic disease management. A versatile encapsulation device that is biocompatible, scalable, and easy to administer, retrieve, or replace has yet to be validated for clinical applications. Here, we report on a cargo-agnostic, macroencapsulation device with optimized features for protein delivery. It is compatible with adherent and suspension cells, and can be administered and retrieved without burdensome surgical procedures. We characterized its biocompatibility and showed that different cell lines producing different therapeutic proteins can be combined in the device. We demonstrated the ability of cytokine-secreting cells encapsulated in our device

SUBMITTER: Grogg J 

PROVIDER: S-EPMC10393802 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature