An Atlas of the Knee Joint Proteins and Their Role in Osteoarthritis Defined by Literature Mining.

ABSTRACT: Osteoarthritis (OA) is the most prevalent rheumatic pathology. However, OA is not simply a process of wear and tear affecting articular cartilage but rather a disease of the entire joint. One of the most common locations of OA is the knee. Knee tissues have been studied using molecular strategies, generating a large amount of complex data. As one of the goals of the Rheumatic and Autoimmune Diseases initiative of the Human Proteome Project, we applied a text-mining strategy to publicly available literature to collect relevant information and generate a systematically organized overview of the proteins most closely related to the different knee components. To this end, the PubPular literature-mining software was employed to identify protein-topic relationships and extract the most frequentl

SUBMITTER: Paz-Gonzalez R 

PROVIDER: S-EPMC10393810 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature