A novel inflammatory endotype diagnostic model based on cytokines in chronic rhinosinusitis with nasal polyps.

ABSTRACT:

Background

Type 2 CRSwNP is characterized by severe symptoms, multiple comorbidities, longer recovery course and high recurrence rate. A simple and cost-effective diagnostic model for CRSwNP endotype integrating clinical characteristics and histopathological features is urgently needed.

Objective

To establish a clinical diagnostic model of inflammatory endotype in CRSwNP based on the clinical characteristics, pathological characteristics, and cytokines profile in the polyp tissue of patients.

Methods

A total of 244 participants with CRSwNP were enrolled at 2 different centers in China and Belgium from 2018 to 2020. IL-5 level of nasal polyp tissue was used as gold standard. Clinical characteristics were used to establish diagnostic models. The area under the receiver

SUBMITTER: Chen M 

PROVIDER: S-EPMC10393814 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature