End-stage kidney disease: a never healing wound leading to another never healing wound, renal cancer.

ABSTRACT:

Background

End-stage kidney disease and acquired cystic kidney disease are the final stages of chronic kidney disease, leading to loss of kidney function and frequent development of tumours. It has been suggested that an inflammatory microenvironment may be responsible for the progressive kidney remodelling and cancer development.

Methods

Our aim was to analyse gene expression suggested to be involved in the remodelling of kidneys in end-stage kidney disease, and in the development of preneoplastic lesions and tumours. Immunohistochemistry was employed to assess the cellular localisation of different genes involved in these pathways on representative tissue sections.

Results

Cellular (αSMA positive naïve activated fibroblasts, endothelial cells, macrophages) and non-c

SUBMITTER: Docs J 

PROVIDER: S-EPMC10393832 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature