Oral antimicrobial agents in patients with short bowel syndrome: worth a try!

ABSTRACT:

Background

The use of oral antimicrobial agents in patients with short bowel syndrome (SBS) is challenging due to the changes in gastrointestinal anatomy that may result in diminished absorption and altered drug bioavailability. Prospective studies evaluating bioavailability of antimicrobial agents after oral administration in SBS patients are lacking.

Objectives

To determine the bioavailability of orally administered antimicrobial agents commonly used for treatment in SBS patients to guide clinical decision making when faced with infections.

Methods

We performed an explorative, clinical study investigating the pharmacokinetics (PK) of clindamycin, ciprofloxacin, flucloxacillin and fluconazole in SBS patients with intestinal failure. Participants received a combinatio

SUBMITTER: Korzilius JW 

PROVIDER: S-EPMC10393866 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature