Histone modifications in drug-resistant cancers: From a cancer stem cell and immune evasion perspective.

ABSTRACT: The development and immune evasion of cancer stem cells (CSCs) limit the efficacy of currently available anticancer therapies. Recent studies have shown that epigenetic reprogramming regulates the expression of characteristic marker proteins and tumor plasticity associated with cancer cell survival and metastasis in CSCs. CSCs also possess unique mechanisms to evade external attacks by immune cells. Hence, the development of new strategies to restore dysregulated histone modifications to overcome cancer resistance to chemotherapy and immunotherapy has recently attracted attention. Restoring abnormal histone modifications can be an effective anticancer strategy to increase the therapeutic effect of conventional chemotherapeutic and immunotherapeutic drugs by weakening CSCs or by rendering t

SUBMITTER: Jin ML 

PROVIDER: S-EPMC10394043 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature