Coordinated human sleeping brainwaves map peripheral body glucose homeostasis.

ABSTRACT: Insufficient sleep impairs glucose regulation, increasing the risk of diabetes. However, what it is about the human sleeping brain that regulates blood sugar remains unknown. In an examination of over 600 humans, we demonstrate that the coupling of non-rapid eye movement (NREM) sleep spindles and slow oscillations the night before is associated with improved next-day peripheral glucose control. We further show that this sleep-associated glucose pathway may influence glycemic status through altered insulin sensitivity, rather than through altered pancreatic beta cell function. Moreover, we replicate these associations in an independent dataset of over 1,900 adults. Of therapeutic significance, the coupling between slow oscillations and spindles was the most significant sleep predictor of ne

SUBMITTER: Vallat R 

PROVIDER: S-EPMC10394167 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature