Mutant HTT does not affect glial development but impairs myelination in the early disease stage.

ABSTRACT:

Introduction

Huntington's disease (HD) is caused by expanded CAG repeats in the huntingtin gene (HTT) and is characterized by late-onset neurodegeneration that primarily affects the striatum. Several studies have shown that mutant HTT can also affect neuronal development, contributing to the late-onset neurodegeneration. However, it is currently unclear whether mutant HTT impairs the development of glial cells, which is important for understanding whether mutant HTT affects glial cells during early brain development.

Methods

Using HD knock-in mice that express full-length mutant HTT with a 140 glutamine repeat at the endogenous level, we analyzed the numbers of astrocytes and oligodendrocytes from postnatal day 1 to 3 months of age via Western blotting and immunocytochemistr

SUBMITTER: Yang S 

PROVIDER: S-EPMC10394243 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature