Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus.

ABSTRACT:

Background & aims

The risk of hepatocellular carcinoma (HCC) remains after achieving a sustained virological response (SVR) in patients with chronic hepatitis C (CHC). Epigenetic abnormalities might be key regulators in the development of HCC. This study aimed to identify the genes involved in hepatocarcinogenesis after an SVR.

Methods

DNA methylation in liver tissue was compared between 21 CHC patients without HCC and 28 CHC patients with HCC, all of whom had achieved an SVR. Additional comparisons with 23 CHC patients before treatment and 10 normal livers were performed. The characteristics of a newly identified gene were explored in vitro and in vivo.

Results

We found that the transmembrane protein no. 164 (TMEM164) gene was demethylated by hepatitis C virus infect

SUBMITTER: Nishikawa M 

PROVIDER: S-EPMC10394272 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature