Glucuronic acid metabolites of phenolic acids target AKT-PH domain to improve glucose metabolism.

ABSTRACT:

Objective

Phenolic acids widely exist in the human diet and exert beneficial effects such as improving glucose metabolism. It is not clear whether phenolic acids or their metabolites play a major role in vivo. In this study, caffeic acid (CA) and ferulic acid (FA), the two most ingested phenolic acids, and their glucuronic acid metabolites, caffeic-4'-O-glucuronide (CA4G) and ferulic-4'-O-glucuronide (FA4G), were investigated.

Methods

Three insulin resistance models in vitro were established by using TNF-α, insulin and palmitic acid (PA) in HepG2 cells, respectively. We compared the effects of FA, FA4G, CA and CA4G on glucose metabolism in these models by measuring the glucose consumption levels. The potential targets and related pathways were pre

SUBMITTER: Gao J 

PROVIDER: S-EPMC10394347 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature