Associations between serum cholesterol and immunophenotypical characteristics of circulatory B cells and Tregs.

ABSTRACT: Blood lipids play a major role in the manifestation of cardiovascular diseases. Recent research suggested that there are connections between cholesterol levels and immunological alterations. We investigated whether there is an association between serum cholesterol levels (total, HDL, and LDL) and immune cells (B cell and regulatory T cells [Tregs]). The analysis was based on data from 231 participants of the MEGA study in Augsburg, Germany, recruited between 2018 and 2021. Most participants were examined two different times within a period of 9 months. At every visit, fasting venous blood samples were taken. Immune cells were analyzed immediately afterward using flow cytometry. Using multivariable-adjusted linear regression models, the associations between blood cholesterol concentrations

SUBMITTER: Schmitz T 

PROVIDER: S-EPMC10394386 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature