PIK3R3 is a candidate regulator of platelet count in people of Bangladeshi ancestry.

ABSTRACT:

Background

Blood platelets are mediators of atherothrombotic disease and are regulated by complex sets of genes. Association studies in European ancestry populations have already detected informative platelet regulatory loci. Studies in other ancestries can potentially reveal new associations because of different allele frequencies, linkage structures, and variant effects.

Objectives

To reveal new regulatory genes for platelet count (PLT).

Methods

Genome-wide association studies (GWAS) were performed in 20,218 Bangladeshi and 9198 Pakistani individuals from the Genes & Health study. Loci significantly associated with PLT underwent fine-mapping to identify candidate genes.

Results

Of 1588 significantly associated variants (P < 5 × 10^-8) at 20 l

SUBMITTER: Burley K 

PROVIDER: S-EPMC10394561 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature