Longitudinal Follow-Up of Participants With Tobacco Exposure and Preserved Spirometry.

ABSTRACT:

Importance

People who smoked cigarettes may experience respiratory symptoms without spirometric airflow obstruction. These individuals are typically excluded from chronic obstructive pulmonary disease (COPD) trials and lack evidence-based therapies.

Objective

To define the natural history of persons with tobacco exposure and preserved spirometry (TEPS) and symptoms (symptomatic TEPS).

Design, setting, and participants

SPIROMICS II was an extension of SPIROMICS I, a multicenter study of persons aged 40 to 80 years who smoked cigarettes (>20 pack-years) with or without COPD and controls without tobacco exposure or airflow obstruction. Participants were enrolled in SPIROMICS I and II from November 10, 2010, through July 31, 2015, and followed up through July 31, 2021.

SUBMITTER: McKleroy W 

PROVIDER: S-EPMC10394572 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature