Genetic Architecture of Dilated Cardiomyopathy in Individuals of African and European Ancestry.

ABSTRACT:

Importance

Black patients with dilated cardiomyopathy (DCM) have increased familial risk and worse outcomes than White patients, but most DCM genetic data are from White patients.

Objective

To compare the rare variant genetic architecture of DCM by genomic ancestry within a diverse population of patients with DCM.

Design

Cross-sectional study enrolling patients with DCM who self-identified as non-Hispanic Black, Hispanic, or non-Hispanic White from June 7, 2016, to March 15, 2020, at 25 US advanced heart failure programs. Variants in 36 DCM genes were adjudicated as pathogenic, likely pathogenic, or of uncertain significance.

Exposure

Presence of DCM.

Main outcomes and measures

Variants in DCM genes classified as pathogenic/likely pathogenic/uncertain si

SUBMITTER: Jordan E 

PROVIDER: S-EPMC10394581 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature