A cuproptosis-related lncRNA signature predicts the prognosis and immune cell status in head and neck squamous cell carcinoma.

ABSTRACT:

Introduction

The incidence of head and neck squamous cell carcinoma (HNSCC), one of the most prevalent tumors, is increasing rapidly worldwide. Cuproptosis, as a new copper-dependent cell death form, was proposed recently. However, the prognosis value and immune effects of cuproptosis-related lncRNAs (CRLs) have not yet been elucidated in HNSCC.

Methods

In the current study, the expression pattern, differential profile, clinical correlation, DNA methylation, functional enrichment, univariate prognosis factor, and the immune effects of CRLs were analyzed. A four-CRL signature was constructed using the least absolute shrinkage and selection operator (LASSO) algorithm.

Results

Results showed that 20 CRLs had significant effects on the stage progression of HNSCC. Sixteen

SUBMITTER: Zheng X 

PROVIDER: S-EPMC10394648 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature