Causal effect of early life adiposity on gestational diabetes mellitus and mediating roles of lipidomic biomarkers.

ABSTRACT:

Objective

The causal relationship between early life adiposity and gestational diabetes mellitus (GDM) and the underlying mechanisms remains unclear. This study aimed to investigate the independent causal association between early life adiposity and GDM and identify potential metabolic mediators and their mediating effects on this relationship.

Methods

Using genome-wide association study (GWAS) summary statistics from the publicly available database of early life adiposity (5,530 cases and 8,318 controls) and GDM (11,279 cases and 179,600 controls), a two-step, two-sample Mendelian randomization (MR) was conducted to estimate the causal mediation effects of lipidomic biomarkers including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C

SUBMITTER: Li C 

PROVIDER: S-EPMC10394696 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature